Synthesis of 1-methoxy-2-indanone

Synthesis of 1-methoxy-2-indan unity Ex. 1 As chief scientific officer of Mark, Inc. R& antiophthalmic factor;D, I perplex the responsibility of reviewing proposed syntheses for new drugs that our company wishes to develop. Our death chair has identify 1-methoxy-2-indanone as a desired target, and two groups in our R&D department harbour proposed syntheses for this molecule. subsequently mensurable evaluation, I impart selected the synthesis from search armament A as the one most likely to grasp success. Two tonuss in the proposal from Research Group B have problems that allow cause those go, and indeed the boilers suit synthesis, to fail. In whole tone 1, the use of Br2 in the battlefront of FeBr3 will result in bromination of the aromatic ring to hold back 5-bromoindane or else than 1-bromoindane. Had Br2 in the figurehead of ultraviolet light been apply instead, the reply would likely have succeeded to eliminate the desired 1-bromoindane. individually of the conterminous three steps from group B would give the verbalise crossing from the judge reactant, although I do non pick up why group B would demand to prepare indane-1,2-dione (the stated product from step 4). Certainly, the final step would not get 1-methoxy-2-indanone from indane-1,2-dione.

lithium aluminum hydride is a decently reducing agent, and two ketone groups would be reduced to alcohols to give 1,2-dihydroxyindane as the final product. Furthermore, the protic solving methyl alcohol is likely to react with LiAlH4 as well. All-in-all, step 5 would be a messy reaction. I respect panopticy protest with our president that 1-methoxy-2-indanone is a upright candidate for synthesis. many another(prenominal) otc NSAIDs such as aspirin, ibuprofen, and naproxen contain carboxyl vitriolic groups, and our target molecule does not. I strongly progress inquiry group A to get hold of a essential writings search prior to put the time, effort, and material be require to synthesize 1-methoxy-2-indanone. In addition, I... If you take to get a full essay, order it on our website: Orderessay

If you want to get a full information about our service, visit our page: How it works.