Thursday, February 28, 2013

Multi-Step Synthesis of Benzocaine

CHEM360 Experiment 17 ReportDate: 3 June 2012

educatee Name: Colin L EvansID Number: 2990817


Multi-step Synthesis of Benzocaine


The simple objective of this experiment is to provide a practical vitrine of the synthesis of an organic compound over the parentage of eight-fold steps.

Reaction equation(s):


Throughout this organic chemistry course there have been several theoretical questions on how to flip a certain organic compound from basic material. entirely questions assume that one has access to unlimited reagents and also assumes extraneous the time required to perform these multi level synthesises. This experiment is an positive example of the synthesis of an organic compound from basic material.

The supreme goal of this experiment is to synthesize benzocaine from p-nitrotoluene. In set up to achieve this, the following multiple steps result be employed:

1. The reduction of p-nitrotoluene to create p-methylaniline. The reducing agent for this phase is a metal sultry combination, tin and hydrochloric acid.

2. Acetylation of p-methylaniline to create p-methylacetanilide.

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present acetic anhydride will be used to prepare the atomic number 7 substituted acetamide. This is conducted to make the amine group, which is a very stong ortho and para enjoin activator on an aromatic ring, a lesser strength activator so that the oxidation of the methyl group can proceed.

3. Oxidation of p-methylacetanilide. present the methyl group on p-methylaniline is oxidized with potassium permanganate to translate the methyl group into a carboxyl-group and ultimate create p-acetamidobenzoic acid.

4. Hydrolysis of p-acetamidobenzoic acid will transform the amide group into an amine group and will create the amino acid p-aminobenzoic acid. Here the condition of the chemical reaction mixture needs to be considered in influence to effect the p-aminobenzoic acid out...If you want to get a full essay, order it on our website: Orderessay

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